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The role of the investigator, therefore, is in large part toclearly describe the objectives of the trial, both to the IRB and to eligible subjects.For example, phase I trials are designed to assess safety and feasibility and not toevaluate ef?cacy.

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Microdialysis study of cefotaxime cerebral distribu-tion in patients with acute brain injury. Effectsof ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance andangina frequency in patients with severe chronic angina: a randomized controlledtrial. Comparing pairs of biopsies allows a betterinterpretation of culture results (contamination). If the ovum gets fertilizedand implants—the blastocyst immediately startsproducing chorionic gonadotropin which isabsorbed into maternal circulation and sustainsthe corpus luteum in early pregnancy

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This event is closely associatedwith the activation of the cyclin E-Cdk2 complex duringthe S phase of the cell cycle (see Fig. A matched control groupsimilar in other respects but not having the adverseevent is selected

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